Relationship between stent length and very long-term target lesion failure following percutaneous coronary intervention for stent thrombosis (ST)-elevation myocardial infarction in the drug-eluting stents era: insights from the EXAMINATION-EXTEND study
Primary result · TLF per 5 mm increase in TSLResult — go to the resultAdjusted hazard ratio 1.07 95% CI 1.01–1.14Authors' conclusion
In STEMI patients, there is a direct relationship between TSL implanted in the culprit vessel and the risk of TLF at 10 years, mainly driven by TLR. The use of DES did not modify this association.
Study context
- Population
- ST-elevation myocardial infarction (STEMI) patients treated with PCI, randomised 1:1 to drug-eluting stents (DES) or bare metal stent (BMS) in the EXAMINATION trialmedian total stent length (TSL) 23 mm
- Participants
- 1,489 patients
- Comparison
- Total stent length and target-lesion failure (TLF)
- Primary endpoint
- TLF:
- TLR
- Target vessel MI
- Definite/probable stent thrombosis
- Follow-up
- 10 years
Methodological detailsextended follow-up (EXAMINATION-EXTEND), multiple-adjusted Cox regression
- Extended follow-up (EXAMINATION-EXTEND)
- Multiple-adjusted Cox regression
Primary result
TLF per 5 mm increase in TSL
Adjusted hazard ratio
1.07
95% CI 1.01–1.14
P = 0.02
TSL per 5 mm increase
adjusted HR 1.07 (95% CI 1.01–1.14); P = 0.02
Per 5 mm increase, as printed
As reported in the abstract
Further findings
TLF by stent type, diameter, overlap (subgroup) · 10 years
- Association consistent regardless of stent type, diameter or overlap
Target vessel MI and stent thrombosis
- No significant relationship between TSL and TV-MI or ST
Original publication
Relationship between stent length and very long-term target lesion failure following percutaneous coronary intervention for ST-elevation myocardial infarction in the drug-eluting stents era: insights from the EXAMINATION-EXTEND study. Am Heart J. Published 4 June 2023. doi:10.
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