Relationship of Ketosis With Myocardial Glucose Uptake Among Patients Undergoing Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/CT for Evaluation of Cardiac Sarcoidosis
Authors' conclusion
We observed a strong inverse relationship between ketosis and patterns of MGU. Longer KD and fasting durations are associated with higher ketosis. However, only KD duration was associated with lower rates of MGU.
Study context
- Population
- Outpatients undergoing FDG-PET for cardiac sarcoidosis evaluation, fasted ≥12 hours, with point-of-care beta-hydroxybutyrate (BHB) measured before FDG injection
- Participants
- 471 outpatients
- Exposure
- Ketogenic diet (KD) duration 1 vs 2 vs ≥3 days; BHB levels and fasting time vs myocardial glucose uptake (MGU) patterns
- KD 1 dayn = 100
- KD 2 daysn = 29
- KD ≥3 daysn = 342
- Outcome
- Relationship of point-of-care BHB, KD duration and fasting duration with patterns of MGU
Main finding
As reported in the abstract
- Strong negative relationship between BHB levels and MGU
- P < 0.0001
- BHB increased with KD duration
- P < 0.0001
- BHB increased with fasting time
- P = 0.0067
- MGU not different across fasting times
- P = 0.6
Observational data: associations, not effects.
Further findings
FDG-PET scan interpretation
- Negative
- 376 (79.83%)
- Positive
- 61 (12.95%)
- Diffuse
- 14 (2.97%)
- NS-MGU
- 20 (4.25%)
Blood glucose
- Not associated with MGU
- P = 0.17
- Weakly associated with BHB levels
- R2=0.03; P<0.001
Original publication
Relationship of Ketosis With Myocardial Glucose Uptake Among Patients Undergoing FDG PET/CT for Evaluation of Cardiac Sarcoidosis. Circ Cardiovasc Imaging. Published 31 July 2024. doi:10.
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