Acute cardiac care & resuscitation
Relevance of age and hypertension for blood pressure targets in comatose survivors of cardiac arrest: a BOX-trial sub-study
Authors' conclusion
Among patients resuscitated after OHCA, older patients and those with a history of hypertension did not benefit from a high MAP target.
Study context
- Population
- Comatose survivors of out-of-hospital cardiac arrest (OHCA)
- Participants
- 789 survivors
- Comparison
- High vs low MAP target, by age and hypertension
- High MAP targetn = 393
- Low MAP targetn = 396reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
1-year all-cause mortality, effect modification by age and hypertension
- Effect of high vs low MAP target modified by age (continuous), potentially favouring low MAP target in younger patients
- P for interaction = 0.03
- Prevalent hypertension did not modify effect of high vs low MAP target
- P for interaction = 0.67
- Risk of primary outcome increased linearly with age
- P < 0.001
Original publication
Relevance of age and hypertension for blood pressure targets in comatose survivors of cardiac arrest: a BOX-trial sub-study. Eur Heart J Acute Cardiovasc Care. Published 19 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it