Heart failure & cardiomyopathies
Renal Tubular Damage and Clinical Outcome in Heart Failure with Preserved Ejection Fraction and Chronic Kidney Disease
Main finding · HF-related eventsResult — go to the resultHazard ratio 2.60 95% CI 1.52–4.72Authors' conclusion
RTD, as assessed by a high UBCR, was associated with the severity and clinical outcomes of HFpEF and CKD, indicating that it could be a feasible marker for HF progression.
Study context
- Population
- Patients with HF with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) hospitalized for acute heart failure (HF) (49% females, mean age 76 ± 12)91 HF-related events
- Participants
- 319 patients
- Exposure
- High UBCR vs normal or low UBCR
- Outcome
- HF-related events:
- HF hospitalizations
- HF deaths
- Follow-up
- Median 5.2 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
HF-related events
Hazard ratio
2.60
95% CI 1.52–4.72
P = 0.0009
High UBCRvs Normal or low UBCR
HR 2.60 (95% CI 1.52–4.72); P = 0.0009
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | C-statistic | P value |
|---|---|---|
| C-statistic with UBCR addedWith UBCR vs Without UBCR · significant NRI and IDI | 0.738 vs. 0.684 | P = 0.0244 |
Prevalence of high UBCR
- Increased with advancing NYHA class and albuminuria
Original publication
Renal Tubular Damage and Clinical Outcome in Heart Failure with Preserved Ejection Fraction and Chronic Kidney Disease. ESC Heart Fail. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →