Heart failure & cardiomyopathies
Sex-Specific Analysis of the Rapid Up-Titration of Guideline-Directed Medical Therapies After a Hospitalization for Acute Heart Failure: Insights from the STRONG-HF Trial
Authors' conclusion
The results of the current analyses suggest that a rapid up-titration of GDMT immediately after an AHF hospitalization can and should be implemented similarly in men and women, as it results in reduction of 180-day all-cause death or heart failure readmission, quality-of-life improvement in both men and women with a similar safety profile.
Study context
- Population
- Men and women hospitalised for acute HF, randomised just before discharge416 (39%) women
- Participants
- 1,078 men
- Comparison
- High-intensity care vs usual care, in women and men
- Primary endpoint
- HF readmission or death
- Follow-up
- 180 days
Methodological detailssex-specific subgroup analysis
- Sex-specific subgroup analysis
Primary result
As reported in the abstract
HF readmission or death, by sex
HIC vs UCAdjusted hazard ratio (95% CI)
Women
0.67(0.40–1.13)
Men
0.57(0.38–0.88)
Further findings
Up-titration to full guideline-directed medical therapies (GDMT) doses · day 90
- Higher proportion of both sexes up-titrated with high-intensity care (HIC) vs usual care (UC)
Quality-of-life improvement
- No significant treatment-by-sex interaction
Safety
Adverse events, including serious or fatal
- No significant treatment-by-sex interaction
Original publication
Sex-Specific Analysis of the Rapid Up-Titration of Guideline-Directed Medical Therapies After a Hospitalization for Acute Heart Failure: Insights from the STRONG-HF Trial. Eur J Heart Fail. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →