Arrhythmias & electrophysiology
Repolarization Injury and Occurrence of Torsades de Pointes During Acute Takotsubo Syndrome
Authors' conclusion
During TS, QTc ≥500 ms was frequent. TdP incidence was low, with unpredictable occurrence and observed almost entirely with QTc ≥500 ms. A normal admission QTc was associated with >98% survival at 1-year postdischarge.
Study context
- Population
- Consecutive takotsubo syndrome patients at a single institution, 2006–201992% female
- Participants
- 259 patients
- Exposure
- QTc <460 ms vs QTc 460-499 ms vs QTc ≥500 ms
- Outcome
- TdP incidence, characteristics of patients with TdP, and association of QTc with postdischarge survival
- Follow-up
- 1 year postdischarge (mortality)
Methodological detailssingle-centre, consecutive patients, with review of published torsades de pointes (TdP) cases
- Single-centre
- Consecutive patients
- With review of published TdP cases
Main finding
As reported in the abstract
In-hospital TdP incidence
0.8%
QTc prolonged (≥460 ms) on admission
129
49.8%
QTc prolonged (≥460 ms) at discharge
140
54%
QTc ≥500 ms on admission or at discharge
98
37.8%
Observational data: associations, not effects.
Further findings
Postdischarge 1-year mortality by admission QTc
- Postdischarge 1-year mortality by admission QTc — Postdischarge mortality associated with admission but not discharge QTc
- P = 0.0056
Published TdP-TS cases (2003–2022)
- Number of published TdP-TS cases
- 38
- TdP events within 48 h of hospitalization
- 80%
- Events with QTc ≥500 ms
- 90%
- Events with QTc ≥600 ms
- 47.5%
- Conditions associated with TdP risk present
- fewer than one-third of patients
Original publication
Repolarization Injury and Occurrence of Torsades de Pointes During Acute Takotsubo Syndrome. JACC Adv. Published 6 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →