Arrhythmias & electrophysiology

Reported Incidence of Atrial Fibrillation Varies by Ethnicity and Presentation in the Multi-Ethnic Study of Atherosclerosis

Circ Arrhythm ElectrophysiolPublished Multi-Ethnic Study of Atherosclerosis

Main finding · AF reported only during hospitalizationResult — go to the resultIncidence rate ratio 0.40 95% CI 0.19–0.75

Authors' conclusion

The reported incidence of AF varies with the inclusion of self-reported data and across ethnic and racial groups. The inclusion of self-reported data increased the reported incidence of AF the most among Chinese individuals and the least among Hispanic participants. In the MESA study, the inclusion of self-reported data reveals heterogeneous changes across ethnic and racial groups, which may be due to differences in true incidence, methods of ascertainment, symptom perception, or health care access, and deserves further exploration.

Study context

Population
Adults aged 45 to 84 years, free from baseline atrial fibrillation (AF) and major cardiovascular events, monitored over 8.4 years (2000–2012)
Participants
6,775 adults
Comparison
Incidence rate ratios and adjusted hazard ratios were calculated with White participants as the referent group
  • Whiten = 2,611reference
  • Chinesen = 800
  • Hispanicn = 1,485
  • Blackn = 1,879
Outcome
AF reported only during hospitalization
Methodological details6 US locations
  • 6 US locations

Main finding

As reported in the abstract

Incidence rate ratio

0.40

95% CI 0.19–0.75

P = 0.009

Chinesevs White
incidence rate ratio 0.40 (95% CI 0.19–0.75); P = 0.009

Further findings

OutcomeIncidence rate ratio (95% CI)P value
AF only via self-reportingHispanicvs White0.29 (0.15–0.51)P < 0.001

Combined overall reported AF incidence

Combined overall reported AF incidence — Overall
6.4%, or 7.72 per 1000 person-years
  • Combined overall reported AF incidence: Chinese vs White P =0.003
  • Combined overall reported AF incidence: Hispanics vs White P <0.001
  • Combined overall reported AF incidence: Blacks vs White P <0.001

Baseline characteristics

Mean age
62.15 (10.24) years
Male
47.1%

Original publication

Reported Incidence of Atrial Fibrillation Varies by Ethnicity and Presentation in the Multi-Ethnic Study of Atherosclerosis. Circ Arrhythm Electrophysiol. Published 25 July 2025. doi:10.1161/circep.124.013620

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