Valvular & structural heart disease
Mitral transcatheter edge-to-edge repair and outcomes according to baseline health status: the RESHAPE-HF2 trial
Authors' conclusion
In patients with HF and moderate-to-severe vSMR, M-TEER showed a consistent trend towards a lower risk of HF hospitalization, with or without cardiovascular death, across all KCCQ-CSS tertiles and improved health status over time.
Study context
- Population
- Patients with symptomatic heart failure (HF) and moderate-to-severe ventricular secondary mitral regurgitation
- Participants
- 505 patients
- Comparison
- Mitral transcatheter edge-to-edge repair (M-TEER) vs medical therapy alone, by baseline KCCQ-CSS tertile
- Primary endpoint
- CV death or HF hospitalization, by baseline KCCQ-CSS tertile
Primary result
As reported in the abstract
CV death or HF hospitalization by baseline KCCQ-CSS tertile
M-TEER vs Medical therapy aloneHazard ratio (CI)
KCCQ-CSS <38.9
.71(.48-1.05)
KCCQ-CSS 38.9-66.1
.50(.29-.85)
KCCQ-CSS >66.1
.73(.38-1.41)
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| KCCQ-CSS improvement/deterioration (responder analysis) · 6 monthsM-TEERvs Medical therapy alone≥5-point improvement | 3.38 (2.09–5.45) | |
| KCCQ-CSS improvement/deterioration (responder analysis) · 6 monthsM-TEERvs Medical therapy alone≥10-point improvement | 3.12 (1.93–5.02) | |
| KCCQ-CSS improvement/deterioration (responder analysis) · 6 monthsM-TEERvs Medical therapy alone≥15-point improvement | 3.25 (1.94–5.45) | |
| KCCQ-CSS improvement/deterioration (responder analysis) · 6 monthsM-TEERvs Medical therapy alone≥5-point deterioration | .34 (.19-.57) | |
| 0.20.5125Odds ratio (log scale) |
- KCCQ-CSS improvement/deterioration (responder analysis): Similar results across other Kansas City Cardiomyopathy Questionnaire (KCCQ) domains and all time points
Total HF hospitalization by KCCQ-CSS tertile
- Similar results across tertiles
- P for trend = 0.48
KCCQ-CSS, total symptom score, overall summary score · 1, 6, 12, and 24 months
- Improved with M-TEER vs medical therapy alone at all time points
- P < 0.05
Original publication
Mitral transcatheter edge-to-edge repair and outcomes according to baseline health status: the RESHAPE-HF2 trial. Eur Heart J. Published 19 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →