Coronary disease & ACS

Restoring microvascular circulation with diagnostic ultrasound and contrast agent: rationale and design of the REDUCE trial

Am Heart JPublished Randomised controlled trial

Study context

Population
Patients presenting with STEMI undergoing primary PCIplanned sample size
Participants
150 patients
Planned comparison
Sonothrombolysis vs sham echocardiography before and after primary percutaneous coronary intervention (pPCI)
Primary endpoint
Infarct size on Cardiac Magnetic Resonance (CMR)
Follow-up
Day 4±2
Methodological detailsdesign paper, prospective, multicentre, patient and outcome blinded, sham-controlled, Follow-up 6 months post pPCI for secondary endpoints
  • Design paper
  • Prospective
  • Multicentre
  • Patient and outcome blinded
  • Sham-controlled
  • Follow-up 6 months post pPCI for secondary endpoints

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Restoring microvascular circulation with diagnostic ultrasound and contrast agent: rationale and design of the REDUCE trial. Am Heart J. Published 27 June 2024. doi:10.1016/j.ahj.2024.06.008

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