Arrhythmias & electrophysiology
Reversible Pulsed Electrical Fields as an In Vivo Tool to Study Cardiac Electrophysiology: The Advent of Pulsed Field Mapping
Authors' conclusion
Reversible electroporation pulses can be applied to myocardial tissue to transiently block electrical conduction.
Study context
- Population
- Swine and patients receiving reversible pulsed electric fields to the atria from a 9-mm lattice-tip catheter12 swine and 9 patients
- Participants
- 17 vs 10
- Comparison
- PFREV-LOW vs PFREV-HIGH
- PFREV-LOWn = 17
- PFREV-HIGHn = 10
- Outcome
- Effect of PFREV on atrial electrograms
Methodological detailspreclinical (swine) and first-in-human
- Preclinical (swine) and first-in-human
Main finding
As reported in the abstract
Animals: immediate post-PFREV electrogram amplitude reduction
74%
Animals: recovery by 5 minutes
78%
Patients: amplitude reduction
69.9%
Patients: recovery by 3 minutes
84%
Further findings
Conduction effects of PFREV at the AV node (5 additional animals)
Transient PR prolongation
Transient AV block
PFREV at putative critical sites in spontaneous tachycardias (3 patients: atypical atrial flutter n=2, AVNRT) · 1-year follow-up
- PFREV reproducibly terminated the tachycardias; ablation rendered them noninducible, without recurrence
Safety
Histology
- Only minimal to no focal, superficial fibrosis
Original publication
Reversible Pulsed Electrical Fields as an In Vivo Tool to Study Cardiac Electrophysiology: The Advent of Pulsed Field Mapping. Circ Arrhythm Electrophysiol. Published 20 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →