Arrhythmias & electrophysiology

Abnormal Atrial Potentials Recorded During Sinus Rhythm or Pacing Represent Substrates for Reentrant Atrial Tachycardia

Circ Arrhythm ElectrophysiolPublished Mechanistic study

Authors' conclusion

AAPs recorded during sinus rhythm/atrial pacing are associated with areas of slow conduction during reentrant AT.

Study context

Population
Patients with reentrant atrial tachycardia; Abnormal atrial potentials (AAPs) (fragmented and split potentials) assessed with the Rhythmia LUMIPOINT algorithm
Participants
104 patients123 reentrant atrial tachycardia (ATs)
Comparison
AAPs during sinus rhythm/atrial pacing vs slow-conduction areas of reentrant AT circuits
Outcome
Relationship between AAPs and AT circuits

Main finding

As reported in the abstract

Overlap between AAP areas during sinus rhythm/atrial pacing and slow-conduction areas along the reentry circuit during AT

93±13%

Further findings

Cumulative AAP area

P = 0.021

OutcomeP value
AAP area at scar peripheryScar associated with localized-reentrant AT vs Scar not participating in localized-reentrant ATP < 0.001
  • AAP area at scar periphery: Scar associated with localized-reentrant AT 3.1 (range 2.4–4.5) cm²
  • AAP area at scar periphery: Scar not participating in localized-reentrant AT 1.0 (range 0.7–1.6) cm²

AAP distribution by AT type

Perimitral ATs: larger AAP areas on lateral wall; roof-dependent ATs: larger AAP areas on roof and posterior wall
P ≤ 0.018 for all comparisons

Original publication

Abnormal Atrial Potentials Recorded During Sinus Rhythm or Pacing Represent Substrates for Reentrant Atrial Tachycardia. Circ Arrhythm Electrophysiol. Published 20 September 2023. doi:10.1161/circep.123.012241

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