Heart failure & cardiomyopathies
Right Atrial Phasic Function Improves CMR-Based Prognostication in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Multicenter Study
Main finding · Composite of all-cause mortality, HF-related hospitalization and cardiac transplantationResult — go to the resultHazard ratio 0.86 CI 0.82–0.90Authors' conclusion
RA conduit strain derived from CMR is an independent predictor of adverse outcomes in patients with HFmrEF, providing incremental prognostic value beyond traditional clinical and imaging-derived risk markers.
Study context
- Population
- Patients with heart failure with mildly reduced ejection fraction (HFmrEF) referred for echocardiography and CMRdevelopment and validation cohorts
- Participants
- 1,317 vs 385
- Exposure
- Right atrial (RA) strain derived from CMR-FT and adverse outcomes in patients with HFmrEF
- Development cohortn = 1,317
- Validation cohortn = 385
- Outcome
- Composite of:
- All-cause mortality
- HF-related hospitalization
- Cardiac transplantation
- Follow-up
- Median 2.8 years (development) and 2.1 years (validation)
Methodological detailsmulticenter, two tertiary medical centers (development), validation cohort from two additional tertiary care centers
- Multicenter
- Two tertiary medical centers (development)
- Validation cohort from two additional tertiary care centers
Main finding
As reported in the abstract
Hazard ratio
0.86
CI 0.82–0.90
P < 0.001
Events by group
Development cohort
243
events
Validation cohort
72
events
RA conduit strain
HR 0.86 (CI 0.82–0.90); P < 0.001
Observational data: associations, not effects.
Further findings
C-index
| Outcome | Development cohort | Validation cohort |
|---|---|---|
| Predictive performance of the full model integrating clinical variables, traditional imaging, and RA strain | 0.80 | 0.81 |
Predictive performance of the full model integrating clinical variables, traditional imaging, and RA strain
- Full model achieved the best predictive performance
Original publication
Right Atrial Phasic Function Improves CMR-Based Prognostication in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Multicenter Study. Eur Heart J Cardiovasc Imaging. Published 28 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →