Heart failure & cardiomyopathies
Right Ventricular Myocardial Work Predicts Pulmonary Capillary Wedge Pressure Rise During Exercise in Heart Failure
Authors' conclusion
RVGWW is a novel predictive parameter that provides a better explanation of RV performance regarding postexercise ΔPCWP than other standard echocardiographic parameters in HFpEF.
Study context
- Population
- Patients with unexplained dyspnea undergoing invasive cardiopulmonary exercise testspatients with adequate data, 21 diagnosed with HFpEF
- Participants
- 41 patients
- Comparison
- RV myocardial work for diagnosis of HFpEF, by invasive cardiopulmonary exercise test
- HFpEFn = 21
- Outcome
- Echocardiographic parameters and exercise haemodynamics, HFpEF vs non-HFpEF
Main finding
As reported in the abstract
- No significant differences in various echocardiographic parameters between HFpEF and non-HFpEF groups
- Higher postexercise pulmonary capillary wedge pressure (PCWP) and mean pulmonary artery pressure in HFpEF patients
Further findings
RV global wasted work (RVGWW) and RV global work efficiency (RVGWE), HFpEF vs non-HFpEF
- HFpEF patients had higher RVGWW and lower RVGWE
Diagnostic performance for HFpEF (AUC)
- RVGWW AUC
- 0.85 (95% CI: 0.73-0.97)
- RVGWE AUC
- 0.83 (95% CI: 0.70-0.96)
- Superior diagnostic performance compared to other echocardiographic parameters
Correlation with postexercise ΔPCWP and exercise PCWP
- RV global constructive work
- r = 0.504; P = 0.001
- RVGWW
- r = 0.621; P < 0.001
- RVGWW independently associated with both after adjustment for confounding factors
Original publication
Right Ventricular Myocardial Work Predicts Pulmonary Capillary Wedge Pressure Rise During Exercise in Heart Failure. JACC Adv. Published 25 June 2025. doi:10.
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