Heart failure & cardiomyopathies
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension
Authors' conclusion
Although there are many RV myocyte contractile deficits in HFrEF-PH, commonly used clinical indices only detect reduced isometric calcium-stimulated force, which is related to deficits in basal and recruitable %DRX myosin.
Study context
- Population
- Patients with HFrEF and pulmonary hypertension undergoing cardiac transplantation (explanted hearts)23 heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH), 9 donors
- Comparison
- Right ventricular (RV) cardiomyocytes from HFrEF-PH vs organ donor controls
- Controlsn = 9reference
- Outcome
- RV myocyte contractile mechanics (calcium-activated isometric tension, peak power, active stiffness) by clinical RV function
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
Increasing sarcomere length increased %disordered-relaxed (DRX) in controls
1.5-fold
Increasing sarcomere length increased %DRX in both HFrEF-PH groups
1.2-fold
Original publication
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension. Circulation. Published 17 May 2023. doi:10.
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