Arrhythmias & electrophysiology
Risk factors and outcomes associated with failed implantable cardioverter-defibrillator shocks
Authors' conclusion
Our study identifies simple clinical risk factors that may be used to risk stratify patients at risk of having a failed ICD shock.
Study context
- Population
- Patients with reduced left ventricular ejection fraction with a primary prevention ICD or cardiac resynchronization therapy-defibrillator enrolled in the Multicenter Automatic Defibrillator Implantation Trials and the Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillator trialpatients with an ICD or cardiac resynchronization therapy-defibrillator
- Participants
- 5,512 patients
- Comparison
- Baseline and post-implantation risk factors for the first occurrence of a failed ICD shock
- Outcome
- Appropriate ICD shocks for VT/VF and at least 1 failed ICD shock for VT/VF
- Follow-up
- 3 years
Main finding
As reported in the abstract
3 years of follow-up
Kaplan-Meier rate of appropriate ICD shocks for VT/VF
14.6%
Kaplan-Meier rate of at least 1 failed ICD shock for VT/VF
3.1%
Further findings
| Outcome | HR (per 10 years younger age) (95% CI) | P value | |
|---|---|---|---|
| Risk factors associated with failed ICD shocksYounger age | 1.21 (1.03–1.42) | P = 0.019 | |
| 0.512Hazard ratio (log scale) |
Risk factors associated with failed ICD shocks
| HR (95% CI) | P value | ||
|---|---|---|---|
| Male sex | 2.21 (1.26–3.86) | P = 0.006 | |
| Heart failure hospitalization after device implantation | 2.06 (1.35–3.16) | P = 0.001 | |
| Successful ICD shock after device implantationMost powerful risk factor for subsequent failed ICD shocks | 6.72 (4.39–10.30) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Risk factors and outcomes associated with failed implantable cardioverter-defibrillator shocks. Heart Rhythm. Published 8 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →