Risk Factors and Outcomes Associated With Heart Failure With Preserved and Reduced Ejection Fraction in People With Chronic Kidney Disease
Authors' conclusion
In a chronic kidney disease population, the rates of HFpEF hospitalizations were greater than that of HFrEF. Risk of ESKD was high but not statically different across HF subtypes. There was a stronger association of HFrEF with mortality.
Study context
- Population
- Adults with CKD free of heart failure (HF) at entry, CRIC study (mean age 57 y, mean eGFR 45 mL/min per 1.73 m²)682 with incident HF
- Participants
- 3,557 adults
- Exposure
- Incident HF with Preserved Ejection Fraction (HFpEF) vs HF with Reduced Ejection Fraction (HFrEF)
- Outcome
- Progression to end-stage kidney disease (ESKD) (chronic dialysis or kidney transplant) and mortality
Methodological detailstime-updated exposure, adjusted Cox proportional hazards
- Time-updated exposure
- Adjusted Cox proportional hazards
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
HFpEFESKD
2.06(1.66–2.56)
HFrEFESKD
1.80(1.36–2.38)
P = 0.42 for difference vs HFpEFHFrEFmortality
2.73(2.24–3.33)
HFpEFmortality
1.99(1.65–2.40)
P = 0.0002 for difference vs HFrEFObservational data: associations, not effects.
Further findings
Incidence rate of HF hospitalization by subtype
P for difference = 0.005
Original publication
Risk Factors and Outcomes Associated With Heart Failure With Preserved and Reduced Ejection Fraction in People With Chronic Kidney Disease. Circ Heart Fail. Published 14 May 2024. doi:10.
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