Heart failure & cardiomyopathies
Aetiology of Chronic Heart Failure in Patients from a Super-Aged Society: The KUNIUMI Registry Chronic Cohort
Authors' conclusion
The KUNIUMI registry chronic cohort showed a change in heart failure aetiology to valvular heart disease in a super-aged society.
Study context
- Population
- Patients with symptomatic chronic HF in a super-aged society (Awaji Island, Japan; 36.3% of inhabitants aged ≥65 years)852 analysed
- Participants
- 1,646 patients
- Outcome
- Main aetiologies of chronic HF
Methodological detailscommunity-based, observational, registry, Enrolment March 2019 to March 2021
- Community-based
- Observational
- Registry
- Enrolment March 2019 to March 2021
Main finding
As reported in the abstract
Aetiology of chronic HF
- Valvular heart disease (most common cause)
- 49.8%
- Ischaemic heart disease
- 35.0%
- Mitral regurgitation
- 27.2%
- Tricuspid regurgitation
- 21.7%
- Mitral and tricuspid regurgitation increased significantly with age
- P < 0.01
- Aortic valve stenosis increased markedly over age 85 years
- P < 0.01
Observational data: associations, not effects.
Further findings
Patient characteristics
- Mean age (years)
- 78.7 ± 11.1
- Female
- 357 (41.9%)
- Proportion of women increased with age; more than half at age ≥85 years
- P < 0.01
- AF prevalence, especially long-standing persistent AF, increased at 70 years
- P < 0.01
- HFpEF proportion at age >75 years
- ≈60%
Atrial functional mitral regurgitation vs other types of mitral regurgitation
- Higher AF prevalence (especially long-standing persistent AF) and larger left atrial volume index
- P < 0.001
Original publication
Aetiology of Chronic Heart Failure in Patients from a Super-Aged Society: The KUNIUMI Registry Chronic Cohort. ESC Heart Fail. Published 23 September 2022. doi:10.
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