Acute cardiac care & resuscitation
Risk of cardiovascular events according to the severity of an exacerbation of chronic obstructive pulmonary disease
Authors' conclusion
Following hospitalization for exCOPD, the risk of cardiovascular complications is increased.
Study context
- Population
- Patients with COPD hospitalized for a CV event in France in 2018–19, with ≥1 hospitalization for exacerbated chronic obstructive pulmonary disease (exCOPD) ≤24 weeks before
- Participants
- 9,840 patients
- Exposure
- Hospitalization for exCOPD ≤1-4 weeks vs 9-24 weeks before the CV event
- Outcome
- Hospitalization for a CV event (CVE), by type
Methodological detailsnationwide hospital discharge database
- Nationwide hospital discharge database
Main finding
As reported in the abstract
Any CVE · ≤4 weeks after exCOPD hospitalization
≤1-4 weeks vs 9-24 weeksOdds ratio (95% CI)
Any exCOPD
3.03(2.90–3.16)
exCOPD requiring mechanical ventilation
6.99(6.09–8.03)
Observational data: associations, not effects.
Further findings
CVE risk ≤4 weeks after exCOPD hospitalization requiring mechanical ventilation
- CVE risk seven times greater if mechanical ventilation was necessary, OR
- 6.99 (95% CI 6.09-8.03)
Risk by type of CVE after exCOPD hospitalization
- NSTEMI, OR (95% CI 4.47-6.34); highest among CVE
- 5.33
- STEMI, OR
- 4.24
- Resuscitated cardiac arrest, OR
- 4.33
- PE, OR
- 4.02
- AF/flutter, OR
- 3.03
- Ischaemic stroke, OR
- 1.93
- Limb events, OR
- 1.34
- Significantly increased (P <0.05) for many other cardiovascular events (CVEs)
Fatal CVEs
- CVEs that were fatal
- Ten percent
Original publication
Risk of cardiovascular events according to the severity of an exacerbation of chronic obstructive pulmonary disease. Eur J Prev Cardiol. Published 20 February 2025. doi:10.
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