Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study
Main finding · DementiaResult — go to the resultHazard ratio 1.6 95% CI 1.3–2.0Authors' conclusion
CHD was associated with an increased risk of dementia compared with the general population, in particular for early onset dementia.
Study context
- Population
- Danish adults with CHD, followed from 1981 to 201246% male in CHD
- Exposure
- Adults with CHD vs matched general population
- CHDn = 10,632
- Outcome
- Hospital diagnosis of dementia
Methodological detailsnationwide Danish registries, matched on sex and birth year (1:10)
- Nationwide Danish registries
- Matched on sex and birth year (1:10)
Main finding
Dementia
Hazard ratio
1.6
95% CI 1.3–2.0
By group
CHD
4%
cumulative incidence
CHDvs General population
HR 1.6 (95% CI 1.3–2.0)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Dementia, CHD without extracardiac defects (subgroup) | 1.4 (1.1–1.8) | |
| Dementia, by CHD severity (subgroup)CHDvs General populationMild-to-moderate CHD | 1.5 (1.1–2.0) | |
| Dementia, by CHD severity (subgroup)CHDvs General populationSevere CHD, incl. univentricular hearts | 2.0 (1.2–3.3) | |
| Dementia, by age at onset (subgroup)CHDvs General populationEarly onset (<65 years of age) | 2.6 (1.8–3.8) | |
| Dementia, by age at onset (subgroup)CHDvs General populationLate onset | 1.3 (1.0–1.8) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study. Circulation. Published 12 February 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →