Sudden death in patients with Ebstein anomaly
Authors' conclusion
Patients with EA are at significant risk for SD.
Study context
- Population
- Patients with Ebstein anomaly evaluated at a high-volume institution over 4 decades
- Participants
- 968 patients
- Outcome
- Incidence and risk factors of SD
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Cumulative incidence of SD from birth
- 10-year cumulative incidence of SD from birth
- 0.8%
- 50-year cumulative incidence of SD from birth
- 8.3%
- 70-year cumulative incidence of SD from birth
- 14.6%
- Prior VT (multivariable predictor of SD), HR
- 6.37, P < 0.001
- HF (multivariable predictor of SD), HR
- 5.64, P < 0.001
- Tricuspid valve (TV) surgery (multivariable predictor of SD), HR
- 5.94, P < 0.001
- Syncope (multivariable predictor of SD), HR
- 2.03, P = 0.019
- Pulmonic stenosis (multivariable predictor of SD), HR
- 3.42, P = 0.001
- Haemoglobin > 15 g/dL (multivariable predictor of SD), HR
- 2.05, P = 0.026
Observational data: associations, not effects.
Further findings
Post-operative SD after TV surgery (subgroup)
- All predictors except syncope significantly associated with post-operative SD on multivariable analysis
Original publication
Sudden death in patients with Ebstein anomaly. Eur Heart J. Published 5 January 2018. doi:10.
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