Risk of incident cardiovascular disease among patients with gastrointestinal disorder: a prospective cohort study of 330 751 individuals
Main finding · Incident CVDResult — go to the resultHazard ratio 1.37 95% CI 1.34–1.41Authors' conclusion
This large-scale prospective cohort study revealed the associations of GIs with an increased risk of incident CVD, in particular CHD and PAD.
Study context
- Population
- Individuals without baseline cardiovascular disease (CVD) from the UK Biobank cohort31,605 incident CVD cases
- Participants
- 330,751 individuals
- Exposure
- GIs vs no GIs
- Outcome
- Incident CVD (coronary heart disease (CHD), cerebrovascular disease, heart failure (HF), peripheral artery disease (PAD))
- Follow-up
- Median 11.8 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
Incident CVD
Hazard ratio
1.37
95% CI 1.34–1.41
P < 0.001
GIsvs No GIs
HR 1.37 (95% CI 1.34–1.41); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incident CVD, by individual GI
- 11 of 15 GIs associated with increased CVD risk after Bonferroni correction: cirrhosis, non-alcoholic fatty liver disease, gastritis and duodenitis, irritable bowel syndrome, Barrett's esophagus, gastroesophageal reflux disease, peptic ulcer, celiac disease, diverticulum, appendicitis, biliary disease
Incident CVD, by sex, age and BMI (subgroups)
- Associations stronger among women, individuals aged ≤60 years and those with BMI ≥25 kg/m²
Original publication
Risk of incident cardiovascular disease among patients with gastrointestinal disorder: a prospective cohort study of 330 751 individuals. Eur Heart J Qual Care Clin Outcomes. Published 30 September 2023. doi:10.
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