Heart failure & cardiomyopathies
Risk of Worsening Heart Failure and All-Cause Mortality Following COVID-19 Vaccination in Patients With Heart Failure: A Nationwide Real-World Safety Study
Authors' conclusion
Receiving an mRNA vaccine was not associated with an increased risk of worsening heart failure, myocarditis, venous thromboembolism, or all-cause mortality.
Study context
- Population
- Danish patients with HF aged 40 to 95 years
- Participants
- 101,786 patients
- Exposure
- mRNA SARS-CoV-2 vaccination vs no vaccination
- Outcome
- All-cause mortality, worsening HF, VTE and myocarditis
- Follow-up
- 90 days
Methodological detailsnationwide registries, 1:1 exact exposure matching on age, sex and HF duration
- Nationwide registries
- 1:1 exact exposure matching on age, sex and HF duration
Main finding
As reported in the abstract
Vaccinated
- All-cause mortality (standardized risk)
- 2.23% (95% CI, 2.10%-2.36%)
- Worsening HF (standardized risk)
- 1.10% (95% CI, −1.01% to 1.19%)
Unvaccinated
- All-cause mortality (standardized risk)
- 2.56% (95% CI, 2.43%-2.70%)
- Worsening HF (standardized risk)
- 1.08% (95% CI, 0.99%-1.17%)
All-cause mortality (standardized risk)
Vaccinated2.23% (95% CI, 2.10%-2.36%)
Unvaccinated2.56% (95% CI, 2.43%-2.70%)
Worsening HF (standardized risk)
Vaccinated1.10% (95% CI, −1.01% to 1.19%)
Unvaccinated1.08% (95% CI, 0.99%-1.17%)
Vaccinated vs UnvaccinatedRisk difference (95% CI)
All-cause mortality
−0.33%(−0.52% to −0.15%)
Worsening HF
0.02%(−0.11% to 0.15%)
Observational data: associations, not effects.
Original publication
Risk of Worsening Heart Failure and All-Cause Mortality Following COVID-19 Vaccination in Patients With Heart Failure: A Nationwide Real-World Safety Study. Circ Heart Fail. Published 28 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →