Heart failure & cardiomyopathies
Left bundle branch area pacing reduces epicardial dispersion of repolarization compared with biventricular cardiac resynchronization therapy
Authors' conclusion
Temporary LBBAP reduces epicardial dispersion of repolarization compared with conventional BiV-epi.
Study context
- Population
- Patients indicated for cardiac resynchronization therapy10 completed protocol
- Participants
- 11 patients
- Comparison
- Left bundle branch area pacing (LBBAP) vs biventricular epicardial pacing (BiV-epi) vs BiV-endo vs baseline rhythm
- Outcome
- Epicardial LV repolarization on electrocardiographic imaging (ECGi) (LVRT-95, LV RT dispersion, mean LV ARI, LV ARI dispersion, RT gradients)
Methodological detailscrossover temporary pacing protocol
- Crossover temporary pacing protocol
Main finding
As reported in the abstract
| Group | LV repolarization time (LVRT-95) | Left ventricular (LV) RT dispersion |
|---|---|---|
| LBBAP | 94.9 ± 17.4 ms | 29.4 ± 6.3 ms |
| BiV-epi | 125.0 ± 29.4 ms | 40.8 ± 11.4 ms |
LV repolarization time (LVRT-95)
LBBAP94.9 ± 17.4 ms
BiV-epi125.0 ± 29.4 ms
Left ventricular (LV) RT dispersion
LBBAP29.4 ± 6.3 ms
BiV-epi40.8 ± 11.4 ms
- LBBAP vs BiV-epi: P = 0.03 — LVRT-95
- LBBAP vs BiV-epi: P = 0.015 — LV RT dispersion
Further findings
| Outcome | LBBAP | Baseline | P value |
|---|---|---|---|
| Mean RT gradientsLBBAP vs Baseline · nonsignificant reduction | 0.74 ± 0.22 ms/mm | 1.01 ± 0.31 ms/mm | P = 0.07 |
Mean LV activation recovery interval (ARI) and LV ARI dispersion
- No significant differences between groups
Original publication
Left bundle branch area pacing reduces epicardial dispersion of repolarization compared with biventricular cardiac resynchronization therapy. Heart Rhythm. Published 27 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →