Heart failure & cardiomyopathies
Prognostic Power of Quantitative Assessment of Functional Mitral Regurgitation and Myocardial Scar Quantification by Cardiac Magnetic Resonance
Authors' conclusion
Mitral regurgitation-fraction and LGE are key quantitative cardiac magnetic resonance biomarkers with differential associations with adverse outcomes in ICM and NICM.
Study context
- Population
- Patients undergoing CMR for cardiomyopathy (EF<50%) assessment, 2001–2017
- Participants
- 1,414 patients
- Exposure
- Ischemic cardiomyopathy (ICM) vs non-ICM (NICM); MR fraction and late gadolinium enhancement (LGE) as prognostic CMR parameters
- ICMn = 782
- NICMn = 632
- Outcome
- All-cause death, heart transplant or LV assist device implantation
- Follow-up
- During
Main finding
As reported in the abstract
Primary end point; MR fraction per 5% increase
Hazard ratio (95% CI)P value
ICM
1.04(1.01–1.07)
P = 0.034NICM
1.09(1.02–1.16)
P = 0.011Per 5% increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | ICM | NICM |
|---|---|---|
| Optimal prognostic thresholds | ||
| MR fraction, moderate FMR | ≥20% | ≥20% |
| MR fraction, severe FMR | ≥35% | ≥35% |
| LGE | ≥5% | ≥2% |
MR fraction × LGE interaction for primary end point
- Significant interaction in ICM
- P = 0.006
- No significant interaction in NICM
- P = 0.971
Original publication
Prognostic Power of Quantitative Assessment of Functional Mitral Regurgitation and Myocardial Scar Quantification by Cardiac Magnetic Resonance. Circ Cardiovasc Imaging. Published 28 July 2023. doi:10.
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