Arrhythmias & electrophysiology
Risk of recurrent ventricular tachyarrhythmia following the occurrence of a first ventricular arrhythmic event in patients with a primary prevention implantable cardioverter-defibrillator
Authors' conclusion
Patients with a primary prevention ICD who experience an episode of VTA are at high risk of recurrent VTA, regardless of baseline risk factors. Recurrent VTA is associated with a pronounced increase in the risk of death.
Study context
- Population
- Heart failure (HF) patients with a primary prevention ICD who experienced a first ventricular tachyarrhythmia (VTA) (MADIT-II, MADIT-RISK, MADIT-CRT, MADIT-RIT, RAID)
- Participants
- 789 patients · 5 ICD trials
- Outcome
- Recurrent VTA (burden and risk factors) and association with all-cause mortality
- Follow-up
- 3 years
Methodological detailslandmark analysis, time-dependent analysis
- Landmark analysis
- Time-dependent analysis
Pooled result
As reported in the abstract
Recurrent VTA after a first VTA
Cumulative probability of ≥1 recurrent VTA episode
60%
Recurrent VTA burden (episodes per patient)
2.8
Risk of recurrent VTA regardless of baseline clinical and echocardiographic risk factors
≥56%
Original publication
Risk of recurrent ventricular tachyarrhythmia following the occurrence of a first ventricular arrhythmic event in patients with a primary prevention implantable cardioverter-defibrillator. Heart Rhythm. Published 22 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it