Arrhythmias & electrophysiology
Temperature-based rate response in a leadless pacemaker system
Authors' conclusion
The temperature-based sensor in a dual-chamber leadless pacemaker system was shown to be effective at modulating pacing rate in response to increased metabolic demand for right ventricular and atrial devices.
Study context
- Population
- Patients implanted with a leadless pacemaker (VR-LP or dual-chamber DR-LP), 6 weeks after implantation
- Outcome
- Normalized slope of sensor-indicated rate vs metabolic workload; proportional if mean slope's 95% CI within 0.65–1.35
- Follow-up
- 6 weeks after implantation
Methodological detailsexercise substudy of the LEADLESS II-Phase 2 and Aveir DR i2i studies, treadmill exercise protocol, prespecified acceptance range 0.65–1.35
- Exercise substudy of the LEADLESS II-Phase 2 and Aveir DR i2i studies
- Treadmill exercise protocol
- Prespecified acceptance range 0.65–1.35
Main finding
As reported in the abstract
Normalised slope of sensor-indicated rate vs metabolic workload (rate-response slope)
| Group | Value | CI | P (within acceptance criteria) |
|---|---|---|---|
| Ventricular | mean 0.93 (SD 0.29) | 0.78-1.08 | P = .001 |
| Atrial | mean 0.91 (SD 0.28) | 0.78-1.05 | P < .001 |
Value
Ventricularmean 0.93 (SD 0.29)
Atrialmean 0.91 (SD 0.28)
CI
Ventricular0.78-1.08
Atrial0.78-1.05
P (within acceptance criteria)
VentricularP = .001
AtrialP < .001
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Temperature-based rate response in a leadless pacemaker system. Heart Rhythm. Published 22 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it