Arrhythmias & electrophysiology
Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes
Authors' conclusion
Patients with AF and HF, regardless of ejection fraction, are at a higher risk of HF events with higher subsequent mortality rates than of stroke/SEE or MB. While HFrEF is associated with a higher risk of HF events than HFpEF, the risk of stroke/SEE and MB is similar between HFrEF and HFpEF.
Study context
- Population
- Patients with atrial fibrillation (AF) enrolled in the ENGAGE AF-TIMI 48 trial12,124 (57.4%) with heart failure (HF) history
- Comparison
- HF outcomes vs stroke/stroke/systemic embolic events (SEE) and major bleeding (MB), by HF history and phenotype
- Primary endpoint
- HF hospitalization (HHF) or HF death, compared with fatal and nonfatal stroke/SEE and MB
- Follow-up
- Median 2.8 years
Primary result
As reported in the abstract
HHF or HF death (rate per 100 py)
P < 0.001
- HF history: HHF or HF death rate per 100 py
- 4.95 (95% CI 4.70-5.20)
- HF history: fatal and nonfatal stroke/SEE rate per 100 py
- 1.77 (95% CI 1.63-1.92)
- HF history: MB rate per 100 py
- 2.66 (95% CI 2.47-2.86)
Further findings
Fatal and nonfatal stroke/SEE and MB, by HF phenotype
- Rates similar by HF phenotype
Mortality after event (HF history)
- After HHF
- 1.29 (95% CI 1.17-1.42)
- After stroke/SEE
- 0.69 (95% CI 0.60-0.78)
- After MB
- 0.61 (95% CI 0.53-0.70)
HF and stroke/SEE events, nonparoxysmal AF
- Higher rate of HF and stroke/SEE events with nonparoxysmal AF regardless of HF history
Original publication
Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes. JACC Clin Electrophysiol. Published 22 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →