Arrhythmias & electrophysiology
Feasibility and Safety of Intravenous Sotalol Loading in Adult Patients With Atrial Fibrillation (DASH-AF)
Authors' conclusion
The DASH-AF trial shows that rapid IV sotalol loading in atrial fibrillation/flutter patients for rhythm control is feasible and safe compared with conventional oral loading with significant cost reduction.
Study context
- Population
- Adults with AF/flutter (atrial arrhythmias) initiating sotalol for rhythm control, 3 centers, 2021–2022Intravenous (IV) loading group, 3 centers
- Participants
- 120 adults
- Exposure
- IV sotalol loading vs conventional 5-dose inpatient oral loading
- IVn = 120
- Outcome
- Safety and feasibility of IV sotalol loading (ΔQTc, dose adjustment)
Methodological detailsmulticenter, open-label, matched control cohort, All patients monitored via mobile cardiac outpatient telemetry for 72 hours
- Multicenter
- Open-label
- Matched control cohort
- All patients monitored via mobile cardiac outpatient telemetry for 72 hours
Main finding
As reported in the abstract
Dose adjustment required
P = 0.003
Observational data: associations, not effects.
Further findings
- Potential cost savings per admission, up to
- $3,500.68
Original publication
Feasibility and Safety of Intravenous Sotalol Loading in Adult Patients With Atrial Fibrillation (DASH-AF). JACC Clin Electrophysiol. Published 22 February 2023. doi:10.
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