Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State
Authors' conclusion
EAT-derived miRNAs exert paracrine effects on the human heart. Indeed miR-92a-3p suppresses the wingless-type MMTV integration site family, member 5a/Rac1/NADPH oxidase axis and improves the myocardial redox state. EAT-derived miR-92a-3p is related to improved clinical outcomes
Study context
- Population
- Patients undergoing cardiac surgery
Methodological detailspaired epicardial adipose tissue (EAT)/atrial biopsy specimens, in vitro cardiomyocyte model, genome-wide association screening, transgenic mouse model, Prognostic cohort followed up for a median of 8 years
- Paired EAT/atrial biopsy specimens
- In vitro cardiomyocyte model
- Genome-wide association screening
- Transgenic mouse model
- Prognostic cohort followed up for a median of 8 years
Main finding
As reported in the abstract
- EAT miR-92a-3p related to lower oxidative stress in human myocardium, confirmed using genetic regulators of miR-92a-3p
- miR-92a-3p reduced nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase-derived superoxide by targeting myocardial WNT5A expression, which regulated Rac1-dependent NADPH oxidase activation
- High EAT miR-92a-3p levels independently related to lower risk of adverse CV events
Original publication
Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State. J Am Coll Cardiol. Published 25 July 2023. doi:10.
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