Valvular & structural heart disease
Role of lipoprotein(a) concentrations in bioprosthetic aortic valve degeneration
Authors' conclusion
High serum Lp(a) is associated with bAV degeneration.
Study context
- Population
- Patients with bioprosthetic aortic valve replacement 2010–2020 and a Lp(a) measurement
- Participants
- 210 patients
- Exposure
- Patients with vs without bioprosthetic aortic valve degeneration; high (≥30 mg/dL) vs lower Lp(a)
- Degenerationn = 33
- Outcome
- Association between Lp(a) levels and bioprosthetic valve degeneration
- Follow-up
- Median 4.4 (IQR 3.7) years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Serum Lp(a)
Lp(a) ≥30 mg/dLHazard ratio (95% CI)P value
Univariable, degeneration
3.6(1.7–7.6)
P = 0.001Multivariable, adjusted by other risk factors
4.4(1.9–10.4)
P = 0.001- Lp(a) higher with degeneration
- P = 0.002
Observational data: associations, not effects.
Further findings
Bioprosthesis degeneration (incidence) · follow-up
- Degeneration observed
- 33 (15.7%)
Original publication
Role of lipoprotein(a) concentrations in bioprosthetic aortic valve degeneration. Heart. Published 29 August 2023. doi:10.
Summarised from the published abstract; every number is checked against it