Arrhythmias & electrophysiology
Role of serotonin and serotonergic-related metabolites in the pathogenesis of vasovagal syncope
Authors' conclusion
Despite the unchanged plasma and platelet serotonin levels, certain serotonergic-related metabolites significantly changed and correlated with hemodynamic parameters during VVS episodes
Study context
- Population
- Patients with recurrent vasovagal syncope undergoing head-up tilt testmean age 45.6±17.0 years
- Participants
- 66 patients
- Comparison
- Head-up tilt test (HUTT)-positive vs HUTT-negative patients; before vs during syncope
- HUTT-positiven = 45
- HUTT-negativen = 21reference
- Outcome
- Plasma and platelet serotonin and plasma serotonergic-related metabolites (5-HTP, 5-hydroxyindoleacetic acid, tryptophan)
- Follow-up
- Resting supine and, in HUTT-positive patients, during syncope
Main finding
As reported in the abstract
- Plasma 5-HTP differed between HUTT-positive and HUTT-negative
- P<.001
- Plasma 5-hydroxyindoleacetic acid differed between HUTT-positive and HUTT-negative
- P=.040
- 5-HTP and 5-hydroxyindoleacetic acid differed before vs after syncope
- P<.001 for all
- Plasma serotonin increased during syncope in drug-free VVS
- P=.037
- Greater serotonin change correlated with shorter time to syncope
- R2=0.38; P=.015
Original publication
Role of serotonin and serotonergic-related metabolites in the pathogenesis of vasovagal syncope. Heart Rhythm. Published 21 September 2024. doi:10.
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