Arrhythmias & electrophysiology
Safety and Outcomes of Transvenous Lead Extraction of Advisory ePTFE-Coated Implantable Cardioverter-Defibrillator Leads: A Multicenter Experience With RELIANCE G
Authors' conclusion
In this large multicenter cohort, TLE of advisory ePTFE-coated ICD leads was associated with high procedural success and low major complication rates despite long lead dwell times. Outcomes were consistent with contemporary TLE experience and do not suggest increased procedural risk attributable to this lead model. The presence of impedance-defined coil calcification did not adversely affect procedural outcomes, supporting TLE at experienced centers when clinically indicated.
Study context
- Population
- Patients undergoing transvenous lead extraction of advisory expanded polytetrafluoroethylene (ePTFE)-coated (RELIANCE, Boston Scientific) implantable cardioverter-defibrillator (ICD) leadspatients undergoing extraction of advisory RELIANCE ICD leads
- Participants
- 423 patients
- Outcome
- Procedural success, complications, and short-term mortality
Methodological details13 centers
- 13 centers
Main finding
As reported in the abstract
- Complete lead removal
- 95.5%
- Clinical success
- 98.8%
- Extraction failed
- 1.2%
- Major complications
- 0.9%
- Procedural deaths
- no procedural deaths
- Thirty-day mortality (primarily among patients undergoing extraction for infection)
- 2.8%
Observational data: associations, not effects.
Further findings
Lead and procedural characteristics
- Mean lead dwell time
- 7.5 ± 5.3 years
- Impedance-defined coil calcification
- 15.1%
- Laser sheaths used
- 63.8%
- Multiple extraction tools used
- 21.7%
Calcified leads
- Calcified leads were associated with longer dwell times but not higher rates of major complications
Original publication
Safety and Outcomes of Transvenous Lead Extraction of Advisory ePTFE-Coated Implantable Cardioverter-Defibrillator Leads: A Multicenter Experience With RELIANCE G. JACC Clin Electrophysiol. Published 3 October 2026. doi:10.
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