A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA: The SAMCRO Randomized Trial
Primary result · Seattle Angina Questionnaire summary score (adjusted mean improvement)Result — go to the resultBetween-group difference 13.12 points 95% CI 9.68–16.56Authors' conclusion
In patients with invasively confirmed ANOCA, a structured multidomain lifestyle intervention provided clinically meaningful improvements in patient-reported health status on top of endotype-guided medical therapy.
Study context
- Population
- Patients with angina and invasive evidence of coronary microvascular dysfunction and/or coronary vasomotor disorder (ANOCA)
- Participants
- 123 patients
- Comparison
- Endotype-guided therapy plus multidomain lifestyle intervention vs endotype-guided therapy alone
- Interventionn = 62
- Controln = 61reference
- Primary endpoint
- Change in Seattle Angina Questionnaire summary score
- Follow-up
- 12 months
Methodological detailsprospective, multicentre, blinded endpoint assessment
- Prospective
- Multicentre
- Blinded endpoint assessment
Primary result
As reported in the abstract
Seattle Angina Questionnaire summary score (adjusted mean improvement)
Between-group difference
13.12 points
95% CI 9.68–16.56
P < 0.001
Interventionvs Control
between-group difference 13.12 points (95% CI 9.68–16.56); P < 0.001
Further findings
| Outcome | Intervention | Adjusted risk ratio (95% CI) | P value | |
|---|---|---|---|---|
| Clinically meaningful improvement in SAQ summary score (≥10-point increase) · 12 months | 77% | 1.98 (1.20–3.26) | P < 0.001 | |
| 0.20.5125Adjusted risk ratio (log scale) |
EuroQol 5-Dimension 5-Level index and Beck Depression Inventory scores
- Significant improvements with intervention
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Multidomain Lifestyle Intervention for Invasively Confirmed ANOCA: The SAMCRO Randomized Trial. JACC Cardiovasc Interv. Published 27 July 2026. doi:10.
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