Oxygenation-sensitive cardiovascular magnetic resonance imaging to identify coronary microvascular and vasomotor dysfunction in angina and no obstructive coronary artery disease
Authors' conclusion
In this small single-centre cohort, we demonstrated the potential of physiologic markers derived from OS-CMR with vasoactive breathing manoeuvres to differentiate ANOCA patients with ICFT confirmed endothelial-dependent CMVD from healthy controls. The clinical utility of this novel approach for non-invasively diagnosing CMVD needs further exploration with external validation in larger studies.
Study context
- Population
- Patients with angina and no obstructive coronary artery disease (ANOCA) diagnosed with endothelium-dependent coronary microvascular and vasomotor dysfunction (CMVD) by invasive coronary function test (ICFT), and healthy participantstotal not printed, subtotals below · ANOCA patients with endothelium-dependent CMVD by ICFT 25 · healthy participants 34
- Index test or model
- Oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) with vasoactive breathing manoeuvres vs clinically performed, gold-standard ICFT
- Target condition
- Endothelial-dependent CMVD in ANOCA patients
Performance
As reported in the abstract
- Area under the curve (apparent discrimination)
- 0.92
- Sensitivity
- 88.9%
- Specificity
- 82.1%
- Positive predictive value
- 82.8%
- Negative predictive value
- 88.5%
- Accuracy
- 85.5%
Further findings
Oxygenation response to vasoactive breathing manoeuvres
- Significantly impaired in ANOCA-CMVD patients compared to healthy participants
Predictors of endothelial-dependent CMVD (LASSO)
- Late-diastolic HV-MOREMI-VAR and peri-systolic BH-MOREMI-AUC emerged as potential predictors
Original publication
Oxygenation-sensitive cardiovascular magnetic resonance imaging to identify coronary microvascular and vasomotor dysfunction in angina and no obstructive coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 27 April 2026. doi:10.
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