Heart failure & cardiomyopathies
Serum Apolipoprotein B to Apolipoprotein A-I Ratio Predicts Mortality in Patients with Heart Failure
Authors' conclusion
Serum ApoB/ApoA-I ratio is an independent predictor for the prognosis of HF patients.
Study context
- Population
- Patients with heart failure (HF)plus independent cohort n = 838
- Participants
- 2,400 patients
- Comparison
- High vs low apolipoprotein B (ApoB)/apolipoprotein A-I (ApoA-I) ratio
- Outcome
- Prognosis (mortality)
Methodological detailstraining and validation cohorts, propensity score matching, independent validation cohort, Optimal cut-off 0.69 identified by ROC curve in training cohort, validated in validation cohort
- Training and validation cohorts
- Propensity score matching
- Independent validation cohort
- Optimal cut-off 0.69 identified by ROC curve in training cohort, validated in validation cohort
Performance
As reported in the abstract
Prognosis (multivariate analysis)
ApoB/ApoA-IHazard ratio (95% CI)P value
Training cohort
1.637(1.201–2.231)
P = 0.002Validation cohort
1.54(1.051–2.257)
P = 0.027PSM cohort
1.645(1.273–2.125)
P < 0.001Independent cohort
1.987(1.251–3.155)
P = 0.004- High ApoB/ApoA-I ratio: significantly poorer prognosis vs low ratio in training, validation, propensity score matching (PSM) and independent cohorts
- P < 0.05
Original publication
Serum Apolipoprotein B to Apolipoprotein A-I Ratio Predicts Mortality in Patients with Heart Failure. ESC Heart Fail. Published 11 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →