Heart failure & cardiomyopathiesCohort study
Serum Markers of Neurodegeneration Are Strongly Linked to Heart Failure Severity and Outcome
- Prospective cohort study
- biobank-linked prospective registry
- single-centre
Authors' conclusion
Neurodegeneration is directly interwoven with the progression of HF.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF), biobank-linked prospective registry at the Medical University of Vienna
- Participants
- 470 patients
- Exposure
- Serum markers of neurodegeneration and outcomes
- Outcome
- Unplanned HF hospitalization and all-cause death
Main finding
As reported in the abstract
Association of neurodegeneration markers with all-cause death and HF hospitalization (crude HR)
- All-cause death, NfL: crude HR
- 4.44 (95% CI 3.02-6.53)
- All-cause death, t-tau: crude HR
- 5.04 (95% CI 2.97-8.58)
- All-cause death, Aβ40: crude HR
- 3.90 (95% CI 2.27-6.72)
- All-cause death, Aβ42: crude HR
- 5.14 (95% CI 2.84-9.32)
- Heart failure (HF) hospitalization, NfL: crude HR
- 2.48 (95% CI 1.60-3.85)
- HF hospitalization, t-tau: crude HR
- 3.44 (95% CI 1.95-6.04)
- HF hospitalization, Aβ40: crude HR
- 3.13 (95% CI 1.84-5.34)
- HF hospitalization, Aβ42: crude HR
- 3.48 (95% CI 1.93-6.27)
Observational data: associations, not effects.
Further findings
Discrimination for all-cause mortality (C-index)
- NfL vs NT-proBNP C-index 0.70 vs 0.72
- P = 0.225
- C-indices of t-tau, Aβ40, Aβ42 and Aβ42:Aβ40 ratio significantly lower
- P < 0.05 for all
Correlation with HF severity (NT-proBNP, NYHA class) and comorbidity burden
- All markers, but not the Aβ42:Aβ40 ratio, correlated with HF severity and comorbidity burden
Original publication
Serum Markers of Neurodegeneration Are Strongly Linked to Heart Failure Severity and Outcome. JACC Heart Fail. doi:10.1016/j.jchf.2024.03.005
Summarised from the published abstract; every number is checked against it