Heart failure & cardiomyopathiesCohort study
Sex-Based Differences in Heart Failure Management and Outcomes: Insights from the French-DataHF Cohort
- Retrospective cohort study
- nationwide
- inverse probability weighting
Authors' conclusion
While females had a better-adjusted prognosis, disparities in guideline-directed medical therapy utilization and cardiology follow-up nonetheless persist.
Study context
- Population
- All French patients diagnosed with heart failure (HF) in the previous 5 years and alive on 1 January 2020 (French-DataHF cohort)48% female
- Participants
- 655,919 patients
- Exposure
- Females vs males with HF
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
Adjusted hazard ratio
0.79
95% CI 0.79–0.80
By group
Females vs Males
aHR 0.79 (95% CI 0.79–0.80)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| Composite of ACM and HF hospitalization · fully adjusted model | 0.85 (0.85–0.86) | |
| 0.512Adjusted hazard ratio (log scale) |
Renin-angiotensin system inhibitor use · IPW-adjusted
No annual cardiology follow-up · IPW-adjusted
All-cause mortality (ACM) by number of cardiology consultations (both sexes)
- Adjusted risk difference, one consultation
- 21%
- Adjusted risk difference, ≥4 consultations
- 41%
Original publication
Sex-Based Differences in Heart Failure Management and Outcomes: Insights from the French-DataHF Cohort. Eur J Heart Fail. Published 20 June 2025. doi:10.1002/ejhf.3733
Summarised from the published abstract; every number is checked against it