Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults
Main finding · Echocardiographic diastolic dysfunction at follow-up, predicted by baseline BFM (women)Result — go to the resultOdds ratio 1.059 95% CI 1.051–1.115Authors' conclusion
Baseline and interval increase in fat quantity via bioimpedance defined differential trajectories of longitudinal cardiac functional deteriorations between sexes.
Study context
- Population
- Community-dwelling older adults without cardiovascular diseaseolder adults (mean age 61 ± 12.7 years, 214 women), median follow-up 4.9 (4.5, 5.2) years
- Participants
- 409 adults
- Exposure
- Effects of sex on body fat composition and aging-related diastolic function, as well as their longitudinal changes
- Womenn = 214
- Outcome
- Echocardiographic diastolic dysfunction at follow-up, predicted by baseline body fat mass (BFM) (women)
- Follow-up
- follow-up
Methodological detailsmeasurements repeated at 5 years, multivariable linear regression
- Measurements repeated at 5 years
- Multivariable linear regression
Main finding
As reported in the abstract
Odds ratio
1.059
95% CI 1.051–1.115
P = 0.002
Baseline BFM
OR 1.059 (95% CI 1.051–1.115); P = 0.002
Observational data: associations, not effects.
Further findings
ΔE/A by ΔBFM and ΔPBF (women)
| β | P value | |
|---|---|---|
| ΔBFMAmong women · independent of baseline BFM/PBF | −0.007 | P = 0.05 |
| ΔPBFAmong women · independent of baseline BFM/PBF | −0.005 | P = 0.047 |
Cardiovascular outcomes by waist hip ratio (WHR) (women)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Baseline WHRAmong women | 1.141 (1.027–1.158) | P = 0.005 | |
| Changes in WHRAmong women | 0.857 (0.790–0.931) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
| Outcome | β | P value |
|---|---|---|
| ΔE/A and ΔE/e' by baseline PBFBaseline PBF · ΔE/A among women | 0.010 | P = 0.028 |
| ΔE/A and ΔE/e' by baseline PBFBaseline PBF · ΔE/e' among men | −0.069 | P = 0.020 |
- ΔE/A and ΔE/e' by baseline percentage body fat (PBF): significant interactions between sex and PBF in predicting ΔE/A (P < 0.05)
Original publication
Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults. JACC Adv. Published 21 August 2025. doi:10.
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