Sex Differences in Achieved Diastolic Blood Pressure and Cardiovascular Outcomes in Elderly Patients With Hypertension
Authors' conclusion
This study shows in elderly hypertensive patients, females have lower achieved DBP. A J-shaped relation between achieved DBP and CVD risk was observed in female, but not male patients. Low achieved DBP is associated with higher CVD risk among females but not males.
Study context
- Population
- Elderly hypertensive patientspatients included in this analysis
- Participants
- 8,355 patients
- Comparison
- The mean achieved diastolic blood pressure (DBP) was compared between male and female participants
Primary result
As reported in the abstract
Mean achieved DBP · throughout the trial duration
- Female patients achieved lower DBP levels than male patients throughout the trial duration
- P < 0.001
- Lower DBP in females in each treatment group
- P < 0.05 for all
Further findings
Cardiovascular risk at DBP >81 mm Hg
| Population | HR (95% CI) | |
|---|---|---|
| Female patients | 1.10 (1.03-1.16) | |
| Male patients | 1.06 (1.01-1.11) | |
| 0.512Hazard ratio (log scale) |
Cardiovascular disease (CVD) risk at mean achieved DBP of <65 mm Hg
| Population | HR (95% CI) | |
|---|---|---|
| Female patients | 2.33 (1.01-5.34) | |
| Male patients | 0.87 (0.12-6.25) | |
| 0.10.31310Hazard ratio (log scale) |
Mean achieved DBP and cardiovascular risk (shape of association)
- J-curve association with cardiovascular risk in females, but not in males
Follow-up
- Median follow-up time
- 3.08 years (Q1-Q3: 2.97-3.25 years)
Original publication
Sex Differences in Achieved Diastolic Blood Pressure and Cardiovascular Outcomes in Elderly Patients With Hypertension. JACC Adv. Published 20 March 2025. doi:10.
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