The vestigial fold in humans: Characterization of a potential novel target for selective cardiac sympathetic denervation
Authors' conclusion
The vestigial fold predominantly contains sympathetic nerve fascicles.
Study context
- Population
- Human vestigial fold samples (67% men, 50.0 ± 12.7 years)87 nerve fascicles analysed
- Participants
- 12 participants
- Outcome
- Characterization of neural structures within the vestigial fold: nerve fascicles ≥50 μm counted and characterized; percentage area of sympathetic, parasympathetic and sensory fibres within fascicles
Methodological detailsimmunohistochemistry, tissue clearing with whole-mount staining
- Immunohistochemistry
- Tissue clearing with whole-mount staining
Main finding
As reported in the abstract
Nerve fibre type, percentage area within each fascicle
- Sympathetic predominance
- P < 0.001
- Nerve fascicles per vestigial fold
- 7.3 ± 4.2
- Fascicle diameter
- 102.0 ± 51.8 μm
- Minimum epicardium-to-fascicle distance
- 487.1 ± 440.2 μm
Further findings
Vestigial fold size
- Length
- 12.7 ± 5.1 mm
- Width
- 3.6 ± 1.7 mm
3-dimensional distribution (whole-mount staining of tissue-cleared sample)
- Confirmed 3-dimensional distribution of predominant sympathetic nerve fascicles
Original publication
The vestigial fold in humans: Characterization of a potential novel target for selective cardiac sympathetic denervation. Heart Rhythm. Published 17 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →