Heart failure & cardiomyopathies
Sex Differences in Clinical Characteristics and Outcomes in Patients Undergoing Heart Transplantation
Authors' conclusion
In this US transplant registry, men and women differed in pre-transplant characteristics. Male sex was independently associated with incident CAV and malignancy even after multivariable adjustment.
Study context
- Population
- HTx recipients in the US Organ Procurement and Transplantation Network, 1995–201924.6% women
- Participants
- 49,200 recipients
- Exposure
- Men vs women
- Outcome
- All-cause mortality, CV mortality, graft failure, cardiac allograft vasculopathy (CAV) and malignancy
- Follow-up
- Median 8.1 years
Methodological detailsprospective registry, multivariable-adjusted, 49 732 events occurred, median age 55 years, interquartile range 46-62
- Prospective registry
- Multivariable-adjusted
- 49 732 events occurred
- Median age 55 years, interquartile range 46-62
Main finding
As reported in the abstract
Post-HTx outcomes (multivariable-adjusted)
Men vs WomenHazard ratio (CI)P value
CAV
1.21(1.13–1.29)
P < 0.001Malignancy
1.80(1.62–2.00)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Pre-transplant characteristicsMenvs WomenIschaemic cardiomyopathy | 3.26 (3.11–3.42) | P < 0.001 | |
| Pre-transplant characteristicsWomenvs MenMalignancies | 0.47 (0.44–0.51) | P < 0.001 | |
| Pre-transplant characteristicsMenvs WomenICU treatment | 1.24 (1.12–1.37) | P < 0.001 | |
| Pre-transplant characteristicsMenvs WomenVentilatory support | 1.24 (1.17–1.32) | P < 0.001 | |
| Pre-transplant characteristicsMenvs WomenVAD support | 1.53 (1.45–1.63) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Pre-transplant characteristics
- Men older and with higher burden of CV risk factors than women
Original publication
Sex Differences in Clinical Characteristics and Outcomes in Patients Undergoing Heart Transplantation. ESC Heart Fail. Published 20 June 2023. doi:10.
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