Aortic & peripheral vascular disease
Sex Differences in DeBakey Type I/II Acute Aortic Dissection Outcomes: The Tokyo Acute Aortic Super-network
Authors' conclusion
Male sex was associated with higher in-hospital mortality for type I/II AAD in the surgical group but not in the medical group.
Study context
- Population
- Patients with DeBakey type I/II (Stanford type A) acute aortic dissection, surgically or medically treated, Japan, 2013–2018surgical n = 2,543
- Participants
- 3,089 patients
- Exposure
- Men vs women
- Outcome
- In-hospital mortality
- Follow-up
- In-hospital
Methodological detailsmulticentre, Japanese registry
- Multicentre
- Japanese registry
Main finding
As reported in the abstract
In-hospital mortality
Each group vs womenOdds ratio (95% CI)P value
Male sexsurgical group (n = 2,543); multivariable analysis
1.71(1.24–2.35)
P < 0.001Sexmedical group (n = 546); no significant association after multivariable adjustment
0.95(0.56–1.59)
P = 0.832- Surgical group: men had higher in-hospital mortality than women
- P = 0.002
- Medical group: women had higher in-hospital mortality than men
- P = 0.039
Observational data: associations, not effects.
Further findings
Preoperative end-organ malperfusion (surgical group)
- Higher in men
- P = 0.003
Cardiac tamponade (medical group)
- Higher in women
- P = 0.004
Presentation (entire cohort)
- Women older, more hyperlipidemia, previous stroke, altered consciousness, shock/hypotension, intramural hematomas and type II dissections
Original publication
Sex Differences in DeBakey Type I/II Acute Aortic Dissection Outcomes: The Tokyo Acute Aortic Super-network. JACC Adv. Published 30 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it