Arrhythmias & electrophysiology
Sex Differences in Outcomes of an Intensive Risk Factor Modification Program in Patients With Atrial Fibrillation
Authors' conclusion
Males and females with AF demonstrate a similar degree of weight loss and fitness gain through structured risk factor management. However, fitness had a much greater benefit for total arrhythmia recurrence in females compared with males, whereas there was a trend toward more AF reversal in males.
Study context
- Population
- Patients with atrial fibrillation (AF) referred for electrophysiology management, BMI ≥27 kg/m², offered risk factor management and tailored exercise programof 1415 referred
- Participants
- 355 patients
- Exposure
- Females vs males undergoing risk factor management
- Femalesn = 121
- Malesn = 234reference
- Outcome
- Sex differences in weight loss, cardiorespiratory fitness gain, and AF recurrence and progression after risk factor management
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Weight loss, fitness gain, AF symptoms by sex
- No sex difference in weight loss
- P=0.86
- No sex difference in fitness gain
- P=0.44
- No sex difference in improvement in AF symptoms
- P=0.35
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Total AF recurrence, weight loss ≥10% vs <10%, by sexWeight loss ≥10%vs Weight loss <10%Males | 0.41 (0.23–0.73) | |
| Total AF recurrence, weight loss ≥10% vs <10%, by sexWeight loss ≥10%vs Weight loss <10%Females | 0.41 (0.20–0.83) | |
| 0.20.5125Hazard ratio (log scale) |
Reversal from persistent to paroxysmal AF · trend
P = 0.079
Clinic attendance
- No sex difference in clinic attendance (58.7% vs 60%)
- P = 0.82
Weight loss, fitness gain, improvement in AF symptoms
- No sex difference in weight loss
- P = 0.86
- No sex difference in fitness gain
- P = 0.44
- No sex difference in improvement in AF symptoms
- P = 0.35
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex Differences in Outcomes of an Intensive Risk Factor Modification Program in Patients With Atrial Fibrillation. Circ Arrhythm Electrophysiol. Published 18 June 2024. doi:10.
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