Arrhythmias & electrophysiology
Sex-specific differences in left atrial reverse remodelling after successful catheter ablation for atrial fibrillation
Authors' conclusion
LARR was attenuated in female AF patients, which might be related to unfavourable outcomes after ablation therapy. The relatively small number of female patients and short follow-up period in this study require further investigations.
Study context
- Population
- Atrial fibrillation (AF) patients who underwent two-dimensional echocardiography before and 6 months after successful ablation without recurrent arrhythmia
- Participants
- 153 AF patients
- Comparison
- Sex-specific differences in left atrial reverse remodelling (LARR) after successful ablation of AF
- Outcome
- LA parameters
- Follow-up
- 6 months after ablation
Main finding
As reported in the abstract
- LA parameters were improved in both sexes
- all P < 0.05
Further findings
BNP concentration · follow-up · higher in females · similar BNP levels at baseline
P = 0.004
| Outcome | Females | Males | P value |
|---|---|---|---|
| ΔLARS · 6 months after ablationSignificantly less improvement in females · linear mixed-effect model | + 5.2% | + 9.2% | P = 0.011 |
Post-procedural LA indices (multivariable)
- Female sex, larger LA volume index, B
- 1.35, P = 0.029
- Female sex, decreased LA reservoir strain (LARS), B
- −1.33, P = 0.012
- Female sex, greater LA stiffness, B
- 0.03, P = 0.003
- Independently associated
Original publication
Sex-specific differences in left atrial reverse remodelling after successful catheter ablation for atrial fibrillation. Eur Heart J Cardiovasc Imaging. Published 5 November 2025. doi:10.
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