Valvular & structural heart disease
Sex Differences in the Clinical Recognition of Significant Aortic Stenosis
Authors' conclusion
Rates of clinical recognition of AS following a diagnostic TTE are low, and vary significantly by sex, AS disease severity, and severe AS phenotype.
Study context
- Population
- Patients with at least moderate aortic stenosis (AS) on diagnostic transthoracic echocardiogram (TTE), US administrative multicentre database48.9% female
- Participants
- 2,036 patients
- Exposure
- Women vs men
- Outcome
- Clinical diagnosis of AS (Internal Classification Diagnosis (ICD) code for AS) after diagnostic TTE, accounting for competing risk of death
- Follow-up
- 1 year
Methodological detailsmulticentre, administrative database
- Multicentre
- Administrative database
Main finding
As reported in the abstract
Clinical recognition of AS (ICD diagnosis)
P = 0.003
- Overall 1-year rate of clinical recognition (at least moderate AS)
- 52.4%
Observational data: associations, not effects.
Further findings
ICD diagnosis in severe AS
Clinical recognition of severe low-gradient AS
P = 0.004
Original publication
Sex Differences in the Clinical Recognition of Significant Aortic Stenosis. JACC Adv. Published 25 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it