Valvular & structural heart disease

Sex Differences in Clinical and Patient-Reported Outcomes in Transcatheter Aortic Valve Implantation: The TAVI-COMIC Trial

JACC AdvPublished analysis of the TAVI-COMIC randomized controlled trial

Authors' conclusion

This study highlights significant sex-specific differences in educational and relationship status, anxiety levels, as well as length of hospitalization and PROs following TAVI. Female patients showed higher anxiety and more frequent postprocedural challenges. These findings underscore the need for tailored pre- and post-procedural care to address the distinct needs of male and female TAVI patients.

Study context

Population
Patients undergoing transcatheter aortic valve implantation (TAVI)patients undergoing TAVI
Participants
299 patients
Comparison
Female vs male patients undergoing TAVI
Methodological details2 tertiary care centers
  • 2 tertiary care centers

Primary result

As reported in the abstract

University degrees

Further findings

In a relationship

Difficulties with daily activities and PROs · Postprocedure

Walking

Shopping

Helplessness

Depression

Discharge to a nursing facility

Anxiety (State-Trait Anxiety Inventory) · before TAVI

Hospital stay · Postprocedure

  • In a relationship: P < 0.001
  • Anxiety (State-Trait Anxiety Inventory): P < 0.001

Original publication

Sex Differences in Clinical and Patient-Reported Outcomes in Transcatheter Aortic Valve Implantation: The TAVI-COMIC Trial. JACC Adv. Published 18 July 2025. doi:10.1016/j.jacadv.2025.102012

Summarised from the published abstract; every number is checked against it

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