Sex Differences in the Density of Lipidic Plaque Materials: Insights From the REASSURE-NIRS MultiCenter Registry
Authors' conclusion
Women harbored greater condensed lipidic plaque features, accompanied by smaller atheroma volume.
Study context
- Population
- Patients with CAD in the REASSURE-NIRS multicentre registry; culprit and nonculprit coronary lesions
- Participants
- 758 patients1,429 lesions
- Exposure
- Women vs men
- Womenn = 150
- Menn = 608reference
- Outcome
- Lipid plaque density index (maximum 4-mm lipid-core burden index / total atheroma volume at 4-mm segment) on NIRS/IVUS
Methodological detailsNIRS/IVUS imaging, multivariable-adjusted
- NIRS/IVUS imaging
- Multivariable-adjusted
Main finding
As reported in the abstract
Adjusted lipid plaque density index
| Group | Culprit lesions | Nonculprit lesions |
|---|---|---|
| Women | 18.2±0.9 | 23.0±2.0 |
| Men | 9.8±0.6 | 7.8±1.4 |
Culprit lesions
Women18.2±0.9
Men9.8±0.6
Nonculprit lesions
Women23.0±2.0
Men7.8±1.4
- Women vs Men: P < 0.001 — culprit lesions
- Women vs Men: P < 0.001 — nonculprit lesions
Observational data: associations, not effects.
Further findings
| Outcome | Women | Men | P value |
|---|---|---|---|
| Adjusted total atheroma volume at 4-mm segment | |||
| Culprit lesions | 50.3±0.4 | 54.2±0.3 | P < 0.001 |
| Nonculprit lesions | 31.5±3.0 | 44.4±2.1 | P < 0.001 |
| Adjusted maximum 4-mm lipid-core burden index | |||
| Culprit lesions | 544.7±29.9 | 501.7±19.1 | P = 0.11 |
| Nonculprit lesions | 288.8±26.7 | 272.7±18.9 | P = 0.51 |
Original publication
Sex Differences in the Density of Lipidic Plaque Materials: Insights From the REASSURE-NIRS MultiCenter Registry. Circ Cardiovasc Imaging. Published 10 May 2023. doi:10.
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