Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Authors' conclusion
Young women with AMI experience more adverse outcomes than men in the year after discharge. Coronary-related hospitalizations were most common, but noncardiac hospitalizations showed the most significant sex disparity.
Study context
- Population
- Patients aged 18 to 55 years with acute myocardial infarction (AMI) (VIRGO study)
- Participants
- 2,979 patients
- Exposure
- Women vs men
- Outcome
- All-cause and cause-specific hospitalizations
- Follow-up
- 1 year after discharge
Methodological details103 US hospitals
- 103 US hospitals
Main finding
As reported in the abstract
Cause-specific hospitalization in the year after discharge (IR per 1,000 person-years)
| Group | Coronary-related hospitalization IR (95% CI) | Noncardiac hospitalization IR (95% CI) |
|---|---|---|
| Women | 171.8 (153.6-192.2) | 145.8 (129.2-164.5) |
| Men | 117.8 (97.3-142.6) | 69.6 (54.5-88.9) |
Coronary-related hospitalization IR (95% CI)
Women171.8 (153.6-192.2)
Men117.8 (97.3-142.6)
Noncardiac hospitalization IR (95% CI)
Women145.8 (129.2-164.5)
Men69.6 (54.5-88.9)
- Sex difference in coronary-related hospitalizations, SHR (95% CI), accounting for deaths
- 1.33 (1.04-1.70); P = 0.02
- Sex difference in noncardiac hospitalizations, SHR (95% CI), accounting for deaths
- 1.51 (1.13-2.07); P = 0.01
Observational data: associations, not effects.
Original publication
Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. J Am Coll Cardiol. Published 9 May 2023. doi:10.
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