Heart failure & cardiomyopathies
Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019
Authors' conclusion
Age-standardized HF rates have decreased over time, with larger decreases in males than females; and with large decreases in high-income and small increases in low-income regions.
Study context
- Population
- People with heart failure (HF) in 204 countries and territories, 1990–2019people with HF in 2019
- Participants
- 56.2 million people
- Exposure
- Females vs males; across country income levels
- Outcome
- Sex differences in HF prevalence, etiology, morbidity and temporal trends across country income level
- Follow-up
- 1990–2019
Methodological detailsGlobal Burden of Disease data, 204 countries and territories, 1990–2019, age-standardized rates
- Global Burden of Disease data
- 204 countries and territories
- 1990–2019
- Age-standardized rates
Main finding
As reported in the abstract
2019; change 1990–2019
| Group | Value | Age-standardized rate 1990 | Age-standardized rate 2019 |
|---|---|---|---|
| Males | decrease in age-standardized rate per 100 000 9.1% | 864.2 | 785.7 |
| Females | decrease in age-standardized rate per 100 000 5.8% | 686.0 | 646.1 |
Value
Malesdecrease in age-standardized rate per 100 000 9.1%
Femalesdecrease in age-standardized rate per 100 000 5.8%
Age-standardized rate 1990
Males864.2
Females686.0
Age-standardized rate 2019
Males785.7
Females646.1
- People with HF in 2019
- 56.2 million (95% UI 46.4-67.8 million)
- Females among people with HF
- 50.3%
- Living in low- and middle-income countries
- 69.2%
- High-income regions: decrease in age-standardized rates (877.5 to 736.8)
- 16.0%
- Low-income regions: increase in age-standardized rates (612.1 to 636.0), largely consistent across sexes
- 3.9%
Observational data: associations, not effects.
Further findings
Years lived with disability · 2019
- YLDs (95% UI 3.3-7.3 million), distributed equally between sexes
- 5.1 million
Etiology trends · 1990–2019
- Increase in age-standardized HF from hypertensive, rheumatic and calcific aortic valvular heart disease; decrease from ischaemic heart disease, with regional and sex differences
Original publication
Sex differences in the etiology and burden of heart failure across country income level: analysis of 204 countries and territories 1990–2019. Eur Heart J Qual Care Clin Outcomes. Published 28 December 2022. doi:10. 1093/ ehjqcco/ qcac088
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