Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study
Authors' conclusion
Psychosocial stress was associated with early subclinical myocardial changes in female participants but not in male participants, suggesting sex-specific pathways linking stress to early myocardial remodeling.
Study context
- Population
- Adults without overt CVD (mean age 54.4±11.0 years)53.9% females
- Participants
- 219 adults
- Exposure
- High vs low perceived stress, by sex
- Outcome
- Association of perceived stress scale scores with native T1 and T2 mapping on CMR, by sex
Methodological detailsdrawn from a prospective repository
- Drawn from a prospective repository
Main finding
As reported in the abstract
Perceived stress scale score predicting native T1
- High-stress females had significantly longer T1 times than low-stress females in both healthy and at-risk groups, and longer T2 times in the at-risk group
- No significant differences in males
- Female: 95% CI 0.088–3.517; P = 0.040
- Male: 94% CI −0.687 to 2.139; P = 0.310
Observational data: associations, not effects.
Further findings
Caregiving burden and perceived emotional support as predictors of T1 (multivariable)
- Caregiving burden: independent predictor of T1 in females
- P = 0.009
- Perceived emotional support: independent predictor of T1 in females
- P = 0.035
- Not predictors in males
Original publication
Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study. Circ Cardiovasc Imaging. Published 9 October 2025. doi:10.
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